زونالین چیست؟
زونالین که با نامZOE شناخته میشود، مخفف اکسید روی اوژنول است. این ماده از ترکیب اکسید روی و اوژنول موجود در روغن میخک ایجاد میشود. از ZOE به عنوان مادهی پرکنندهی دندان یا سمان دندان در دندانپزشکی استفاده میشود.
برخی از مزایای زونالین عبارت است از خواصّ ضدّ باکتریایی، اثرات آرامبخش روی پالپ، هزینهی کم، سهولت دستکاری و زیستسازگاری خوب است. برخی از معایب آن نیز شامل استحکام کم، مقاومت ضعیف در برابر سایش و حلالیّت در مایعات خوراکی است.
ZOE از طریق واکنش اسید-باز بین اکسید روی و اوژنول به عنوان مادهی قالبگیری عمل میکند. این ماده سفت و غیرقابل برگشت است و قابلیت این را دارد که شکل بافتهای دهان را به خود بگیرد. از این ویژگی ZOE در تکنیک مخاطی برداشت قالب استفاده میشود، چرا که بافتهای نرم را فشرده یا جابهجا نمیکند. زونالین را میتوان با افزودنیهای مختلف مخلوط کرد تا خاصیّت آن بسته به کاربرد مورد نظر تغییر کند. این ماده معمولاً با آب یا نمکهای فلزی مخلوط میشود تا خمیری ایجاد کند که پس از گرفتن سخت میشود.
ترکیبات زونالین چیست؟
اجزای ZOE شامل پودر و مواد مایعی است که با هم مخلوط میشوند. این پودر معمولاً حاوی اکسید روی، کلوفون سفید، استات روی و استئارات روی است. مایع آن نیز معمولاً شامل اوژنول و روغن زیتون است. اکسید روی و اوژنول این مواد با هم واکنش نشان میدهند و کلات اوژنولات روی را تشکیل میدهند که جزء اصلی زونالین است. افزودنیهای دیگری مانند آلومینا، رزین و رزین پلی متیل متاکریلات را میتوان برای بهبود استحکام و حلالیّت به این مخلوط اضافه کرد.
وظایف هر یک از اجزای ZOE به شرح زیر است:
اکسید روی: مادهی اصلی زونالین است که با اوژنول واکنش میدهد و کلات اوژنولات روی را تشکیل میدهد. این ماده دارای خواصّ ضدّ میکروبی است.
اوژنول: جزء مایعی است که با اکسید روی واکنش میدهد و کلات اوژنولات روی را تشکیل میدهد. این مایع روغنی بیرنگ تا زرد کمرنگ و معطّر است که از برخی اسانسها، به ویژه از میخک، استخراج میشود. اوژنول دارای اثرات ضدّ التهابی و بیحسکنندهی موضعی روی پالپ دندان است.
رزین سفید: رزینی است که از درختان مخروطی به دست میآید و حاوی اسیدهای رزینی است. این ماده چسبندگی و مقاومت در برابر شکست ZOE را بهبود میبخشد.
استات روی: این ماده یکی از مواد افزودنی است که با ایجاد پیوندهای عرضی بین ذرات اکسید روی، استحکام ZOE را بهبود میبخشد.
استئارات روی: این ماده نیز یکی از مواد افزودنی است که با افزایش حلالیّت اکسید روی به عنوان یک تسریعکننده برای واکنش تولید ZOE عمل میکند.
روغن زیتون: رقیقکنندهای است که باعث کاهش ویسکوزیته و افزایش زمان کار ZOE میشود.

بیشتر بخوانید: زمینه سازی برای هدایت رفتاری موفق در دندانپزشکی کودکان
کاربرد زونالین در دندانپزشکی
ZOE که یکی از تجهیزات دندانپزشکی به حساب می آید وظایف مختلفی در دندانپزشکی دارد، مانند:
- هنگامی که پوسیدگی دندان بسیار عمیق یا نزدیک به اتاقک عصب یا پالپ است، میتوان از آن به عنوان مادهی پرکنندهی دندان برای پرکردن موقت یا آرامبخش استفاده کرد. در واقع، زونالین میتواند درد و التهاب پالپ را کاهش دهد. همچنین میتواند به خوبی دندان را آببندی و از تهاجم باکتریها جلوگیری کند. با این حال، ZOE یک پرکنندهی دائمی نیست زیرا ضعیف و محلول است. از این ماده فقط به صورت موقت تا زمانی که بتوان ترمیمی قطعی انجام داد استفاده میشود. شما میتوانید برای خريد تجهيزات مصرفی دندانپزشكي به سایت دندانت مراجعه کنید.
- می توان از آن به عنوان سمان دندانی برای روکش کردن تاج، بریج، اینله و آنله استفاده کرد؛ چرا که این ماده میتواند بین ساختار دندان و موادّ ترمیمکنندهی آن، حالتی به صورت مهر و موم غیرتحریککننده ایجاد کند. همچنین میتواند به کاهش حساسیّت دندان پس از آمادهسازی یا قالبگیری کمک کند. با این حال، زونالین سمانی دائمی برای روکش کردن محسوب نمیشود؛ زیرا دارای استحکام پایین، مقاومت سایشی کم و حلالیت بالا است. همچنین میتواند با سمانهای رزینی دائمی تداخل ایجاد کند.

بیشتر بخوانید: پست دندان چیست؟
- زونالین در برخی موارد میتواند به عنوان پایهای برای ترمیم آمالگام عمل کند:
اگر ZOE با رزین یا ذرات فلز ترکیب شود میتوان از آن به عنوان پایهای برای ترمیم آمالگام استفاده کرد. این کار باعث افزایش استحکام و مقاومت زونالین در برابر نیروهای متراکم آمالگام میشود. با این حال، ممکن است برای حفرههای عمیق یا ترمیمهای بزرگ مناسب نباشد چرا که میتواند در تنظیم آمالگام اختلال ایجاد کند.
همچنین اگر حفره کمعمق و کوچک باشد میتوان از زونالین به عنوان یک پایه موقت برای ترمیم آمالگام استفاده کرد؛ چرا که باعث کاهش درد و التهاب در پالپ میشود. با این حال، ZOE باید در اسرع وقت با پایهی دائمی جایگزین شود؛ زیرا ضعیف و محلول است.
- از زونالین میتوان به عنوان مادهی قالبگیری برای تکنیک مخاطی استفاده کرد. ZOE در تکنیک مخاطی میتواند از بافتهای دهان بدون جابهجایی آنها قالبگیری کند. زونالین این کار را با جاری شدن در شکافها و پستی و بلندیهای مخاطی بدون اعمال هیچگونه فشاری انجام میدهد. به این ترتیب، شکل مخاط را در حالت غیرعملکردی آن ثبت میکند. علّت استفاده از زونالین به عنوان ماده قالب گیری برای تکنیک مخاطی این است که این ماده دارای ویسکوزیته کم، بازتولید خوب جزئیات، آب دوستی و ابعادی پایدار است. همچنین دارای خواص ضدّ عفونیکننده و ضدّ درد است که میتواند بافتهای ملتهب را تسکین دهد. با این وجود، ZOE دارای معایبی مانند استحکام کم، شکنندگی، سازگاری ضعیف با رزین های اکریلیک و واکنش های آلرژیک احتمالی به اوژنول است.
- از زونالین میتوان به عنوان مادهی پرکنندهی کانال ریشه دندانهای شیری کودکان استفاده کرد.

بهترین ماده برای پر کردن دندان را به نقل از دندانپزشکی میخک بخوانید:
تصمیمگیری درست در مورد مواد پرکننده دندان بسیار مهم است. اگر هنوز در انتخاب تردید دارید، دندانپزشک شما میتواند به شناسایی مناسبترین ماده پرکننده کمک کند. معمولترین مواد پر کردن دندان، آمالگام و کامپوزیت هستند که با توجه به موقعیت دندان در دهان و عمق حفره دندان مورد استفاده قرار میگیرند. آمالگام دوام بیشتر و کامپوزیت زیبایی بیشتری دارد و هر دو گزینههایی مقرونبهصرفه برای پر کردن دندان هستند.
ZOE مادهای است که از دیرباز برای پالپکتومی استفاده میشود. پالپکتومی روشی برای برداشتن بافت پالپ عفونی از دندان شیری است. زونالین برای پر کردن کانال ریشه پس از تمیز کردن و شکل دادن به آن استفاده میشود. این ماده دارای مزایایی به عنوان مادهی پرکنندهی کانال ریشه است، به عنوان مثال این ماده را میتوان به آسانی حمل کرد. همچنین زونالین هزینهی کمی دارد. ZOE زیست سازگاری و قابلیت جذبپذیری خوبی با بافتهای اطراف خود دارد.
همچنین این ماده دارای خواص ضدّ میکروبی، اثرات ضدّ عفونیکننده و ضدّ درد است که از عفونت در کانال ریشه جلوگیری میکند. با این حال، زونالین ممکن است اگر خیلی ضخیم یا چسبناک باشد، کانال ریشه را به طور کامل پر نکند. همچنین ZOE ممکن است به مرور زمان باعث تغییر رنگ تاج دندان شود.
منابع:
https://www.sciencedirect.com/topics/medicine-and-dentistry/zinc-oxide-eugenol Accessed 3/10/2023.
https://www.dental-science.com/zinc-oxide-eugenol-zoe-cement/ Accessed 3/10/2023
https://pubmed.ncbi.nlm.nih.gov/1437045/
https://www.dental-science.com/zinc-oxide-eugenol-zoe-cement/
https://www.dental-tribune.com/news/zinc-oxide-and-propolis-mixture-shows-promising-results/

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may be taken, similar to anastrozole, to lower progesterone.
However, AIs can worsen blood strain ranges, so our
patients solely take them if the nipples start to turn into swollen.
Stacking on this means can considerably improve a user’s results compared to testosterone-only cycles.
An aggressive PCT of hCG, Nolvadex, and Clomid
is also doubtless required on this testosterone
and trenbolone cycle to stop testosterone deficiency and to assist retain outcomes.
There is an extra danger of gynecomastia when taking Deca Durabolin as a outcome
of its average progesterone activity. Deca Durabolin also fits
testosterone, as it requires a lengthy cycle and is a slow-acting steroid.
Presently, 1 million people in Britain are believed to
be taking steroids (6), and up to four million of the US inhabitants (7).
Furthermore, legal steroid alternatives are not prohibited and thus may be purchased online without any legal constraints.
This dramatic elevation in testosterone explains why Dianabol users can experience euphoria during a cycle (due to testosterone having a powerful constructive impact on well-being).
Nonetheless, in 1990, 32 years after it got here to market, Dianabol was banned by the
FDA following the Anabolic Steroids Management
Act. It became unlawful within the US for non-medicinal reasons, because of a new understanding of the
steroid’s potential to trigger extreme side
effects. In drugs, Dianabol was also prescribed to treat the elderly and those suffering from extreme burns, with both
of those folks prone to considerable reductions in muscle mass.
Thus, Dr. Ziegler’s intention wasn’t just to create a compound that was
more anabolic than testosterone but one that would also be less androgenic.
He accomplished this with Dianabol’s androgenic ranking of 60, in comparison with testosterone’s a hundred.
All oral steroids must be taken away from food as meals can decrease the bioavailability
of oral Steroids.
We have discovered this to be a preferable therapy, contemplating
SERMs don’t exacerbate hypertension compared to AIs.
A research found Nolvadex to be efficacious within the therapy of gynecomastia when administering 10 mg/day for one month (8).
Anavar (oxandrolone) is an oral anabolic and one
of many least poisonous steroids we now have seen alongside testosterone.
AIs could additionally be used as a substitute to stop gynecomastia,
offering protection from excessive estrogen and progesterone.
Thus, we solely incorporate them if users start to observe early indicators of gynecomastia.
This is as a result of it does not convert to estrogen, and thus it can worsen ldl
cholesterol ratios. Taking four grams of fish oil per day
might help to stabilize blood stress and was advantageous in a 2013 research (3).
Dianabol, being an oral steroid, will cause liver toxicity; thus, it should not be taken for
an extended interval. This testosterone cycle for beginners,
regardless of being cautiously dosed, is prone
to produce vital will increase in muscular measurement and energy.
Full outcomes typically appear after 4-6 weeks, depending on dosage, food
plan, and training depth.
If you’ve trained your ass off and eaten like a champ, by now you’ll have
gained lbs (6,8-9 kg). This is the place most people
will finish their cycle due to the unwanted effects of extending it additional.
First meant for medical use, it quickly turned a game-changer
for athletes. Because you possibly can take it orally
and it actually works properly with out injections, it earned a particular spot in bodybuilding historical
past. One Other professional bodybuilder who shared his expertise is
featured in a vintage video, discussing his private journey with a Dianabol
alternative supplement. In circumstances of acute liver harm,
users will naturally eat fewer calories, negatively affecting their outcomes when bulking
on Dianabol.
Studies have discovered that prolonged use of AAS (anabolic-androgenic steroids)
may cause a one hundred pc enhance in LDL cholesterol and a 90% reduction in HDL cholesterol (6).
Consequently, broken muscle cells from weight coaching are able to grow notably greater and stronger than earlier than. The above punishments aren’t simply applicable to Dianabol
but to anabolic steroids in general, based on the Controlled Substances Act.
Throughout this ’60s/70s period, bodybuilders could merely go to their doctors and ask for Dianabol (and different steroids)
to get greater and stronger, and their request can be granted.
Steroids’ antagonistic effects weren’t well known, they usually were
one hundred pc authorized.
However, using Dianabol during chopping cycles is an unusual follow.
A Number Of drugs can be taken following Dianabol cycles to assist restore pure
testosterone production. The following is an aggressive PCT protocol designed by Dr.
Michael Scally, a leading professional in hormone substitute.
This was used in a scientific setting on 19 men, by which one hundred pc
of them recovered their natural testosterone manufacturing forty
five days after taking steroids.
Organizations such as the International Olympic Committee (IOC) and the World Anti-Doping Company (WADA) have listed
Dianabol amongst their prohibited substances.
In our experience, his size features are typical of what a newbie can count on when taking average
dosages of 15 mg–20 mg/day for 5–6 weeks. Some users have reported gaining about 7lbs from
running a 50mg dosage for simply over 6 weeks.
It’s essential to notice that individual results may range, and plenty of components corresponding to food regimen, coaching, and total health can influence outcomes.
To maximize the advantages of Dianabol, it’s crucial to comply with a well-designed workout regimen and preserve a balanced food plan. Additionally, understanding the recommended dosage and contemplating potential side effects is important to stop adverse health penalties.
It is crucial to keep in thoughts that consistency
in both training and nutrition plays a major function in the results achieved from
utilizing Dianabol.
We have additionally seen Dianabol having a reductive effect on subcutaneous physique fats due to it primarily being exogenous testosterone, a potent fat-burning hormone.
This isn’t to imply that users can look like Arnold by merely taking
Dianabol; as you can see, he had impressive muscularity whilst a natural
bodybuilder. After taking Dianabol by itself, it can later be
stacked with testosterone and/or Deca Durabolin for larger results when bulking.
Ladies are additionally susceptible to virilization from Dianabol; thus,
it is not a common steroid amongst females. Ingesting alcohol must be
prevented on Dianabol, with research showing
it to be hepatotoxic and thus rising the chances of liver injury (Wilder, 1962).
Dianabol (methandrostenolone) is a bulking steroid utilized by bodybuilders to significantly improve muscle
hypertrophy and energy. In this part, we’ll talk about options
to Dianabol, such as non-steroid dietary supplements and comparisons with other anabolic
steroids. This will provide you with a better understanding of the different options and the way they impact your physique.
Some users additionally report a lift in their general testosterone levels, further enhancing their muscle-building potential.
Nevertheless, it’s value mentioning that Dianabol is a bulking
steroid and thus will not be the most fitted choice for slicing
phases. To obtain the best possible results when using Dianabol,
it’s essential to mix the anabolic complement
with proper diet and coaching. In this section, we’ll focus on dietary pointers and coaching regimens for enhanced efficacy.
The beneficial daily dosage of Dianabol varies depending on individual
objectives and experience, however usually falls inside the vary
of mg per day. It is necessary to consult with a healthcare professional before beginning any
steroid cycle to determine the suitable dosage on your particular wants and to minimize potential risks.
Extended use or excessive doses can result in elevated liver enzymes, which may indicate liver stress.
It is important to observe liver well being throughout a
Dianabol cycle and limit the cycle’s length to reduce potential liver injury.
Dianabol’s advantages for muscle growth lengthen past simply dimension gains; it
may possibly also assist to improve energy and performance in users.
By following dietary tips and incorporating an efficient training regimen, individuals can maximize advantages in power, lean muscle mass, and general
efficiency. It’s crucial for people considering using Dianabol to weigh these unwanted side effects towards the potential advantages and consult a medical professional earlier than starting any cycle.
Dianabol, also called Methandrostenolone, has been used by bodybuilders and athletes for decades to enhance
efficiency and gain muscle mass. Nevertheless, its use in skilled
sports has been largely disputed as a result of its doubtlessly harmful unwanted effects.
In most professional sports, Dianabol is taken into account
a banned substance and its use can result in disqualification, fines, and suspensions.
For instance, those who are bulking typically
will eat in a generous calorie surplus to assist muscle and strength results.
A pure supplement designed to imitate the intense muscle-building results of dianabol, legally without all
unwanted aspect effects. Traditionally, therapeutic doses of anabolic steroids
have effectively treated cachexia and osteoporosis. In instances of acute liver injury, users will naturally consume fewer calories, negatively affecting their outcomes when bulking on Dianabol.
The particular person reported with the power to lift heavier weights and noticed significant enhancements in muscle mass.
As the popularity of Dianabol continues to develop, so does the
interest in understanding the earlier than and after results
of its use. Dianabol in excessive doses could considerably compromise a user’s health,
particularly in regard to cholesterol and liver values.
We have treated patients with hypertension on account of utilizing Dianabol
along side other anabolic steroids. Arnold Schwarzenegger, a legendary bodybuilder
and former Mr. Olympia, has been open about his use of Dianabol during his profession. He,
like many others, skilled significant muscle-building and bulking
results from this powerful oral anabolic steroid.
The compound enhances protein synthesis, which in turn leads to better restoration and growth of muscle tissue.
Additionally, it’s known to increase nitrogen retention and glycogenolysis, additional supporting the development of muscular strength.
Throughout a 4-week dianabol before and after pics cycle,
users can count on speedy weight achieve with gains of up to lbs of muscle mass.
The precise amount of muscle gained will rely upon components corresponding to genetics, diet, and exercise
routine.
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